Abstract: As quantum computers (QC) evolve in scale and quality, moving out of research labs and integrating them with high-performance computing (HPC) becomes the next step in their evolution. At the same time, the HPC field continues to evolve and promises potential for further expansion when integrated with quantum computing. Once integrated, quantum computers can accelerate classical applications, taking over tasks tuned to exploit their unique processing capabilities, similar to the way other accelerators such as graphics processing units are used with HPC today. However, while the need to integrate HPC and QC systems is clear, achieving it requires a deep understanding of both quantum and classical technologies, and the merging of two different fields, each with its peculiar skillset, challenges, and nuances. In this panel we aim to answer questions about the features that are critical for the integration of classical and quantum systems. The discussion will be framed around the infrastructure required to realize a new architectural paradigm in quantum computing designed to support integration into classical HPC systems. We’ll focus on a variety of issues including: the growing and changing quantum computers of multiple types, the need for low latency connectivity, collaboration between the many stakeholders (i.e. HPC centers and HPC infrastructure vendors, integrators, quantum control designers, QPU and software providers) and more. This panel will be one of the very first discussions bringing together experts from all the different parts of the stack and the value chain to discuss the challenges and the possible paths forward for quantum integration within HPC environments.